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1. Denomination
Parlodel

2. Active Substance
Bromocriptine

3. Indications for Use.
The medication should be used in treatment of infertility in women and prolactin-dependant menstrual disorders, polycystic ovarian syndrome; premenstrual syndrome, anovulatory cycles (additionally to treatment with antiestrogens); hyperprolactinemia in men; acromegalia; prolactinomas; depression or delimitation of lactation (according to medical indications); insipient post-natal mastitis, post-natal breast engorgement, mastalgia, and other diseases of lacteal glands with benign formations; Parkinson disease.

4. Action
Parlodel has the ability to delimitate the secretion prolactin � an anterior lobe hormone of pituitary gland without having any influence on the levels of other pituitary hormones, if their limits are normal.

Prolactin can be used in case of up-keep and on-set of lactation. When not used during the period of lactation, the medication will cause increased secretion, which can lead to distortion of menstrual cycles and ovulation as well as pathologic lactation.

5. Posology and Administration
Parlodel medication needs to be taken during meals.
In case of treating women with menstrual cycle disruption and infertility, the medication should be used 2-3 times per day in dose of 1.25mg (half a pill). The dose can be increased if the effect in insufficient up to reaching the level of 5-7.5mg per day, with the same number of intakes. It is recommended to continue treatment until the menstrual cycle resets and ovulation is restored. The treatment can be repeated for several cycles in order to prevent backsets.

When the medication is used for treatment of premenstrual syndrome, the treatment should start on the 14th day of menstrual cycle with the daily dose of 1.25mg (half a pill). It is recommended to increase the dose gradually by 1.25mg per day until reaching the level of 5mg per day, which should be taken until the menstrual cycle starts.

In fortification of blood hormone prolactin in men the dose should be half a tablet (1.25mg), which should be used several times a day, with gradual increasing of the dose to 5-10mg per day (from 2 to 4 tablets).
For treatment of prolactinomas the medication should be taken in dose of 1.25mg (half a pill) for 2-3 intakes per day. The dose can be gradually increased upt o several pills per day, but it is needed to control the adequate lowering of prolactin concentration in plasma.
For treatment of acromegalia the starting dose should be half a pill (1.25mg), which should be taken 2-3 times per day. In further treatment the dose can be gradually increased, if there are no side effects and clinical effect is insiffucient until reaching the level of 10-20mg (from 4 to 8 tablets).
When the medication is used for depression of lactation for start of treatment it is necessary to use half a tablet two times per day (for breakfast and dinner), and then take 1 tablet two times per day for a period of two weeks. In order to prevent start of lactation the use of the medication should start several hours after abortion or birth. But it is only possible to use it after vitally important functions stabilize. After 2-3 days when the drug was cancelled, there is a risk of having minor excretions. Such incidents can be eliminated by renewing intake of the medication with the same dose for another week.

When the medication is used for brast engorgement in post-natal period, it should be taken in single-shot dose of 2.5mg (1 tablet). The medication should not be taken more often than once in 6-12 hours and it will be accompanied with undue lactation depression.
In cases of nascent mastitis in post-natal period the medication should be used in the same doses and according to the same scheme as for depression of lactation. It is also recommended to add antibiotic for such treatment.
For treatment of lacteal glands with benign disease the medication should be used in dose of 1.25mg per day (half a pill) in 2-3 intakes per day. It is allowed to gradually increase the daily dose up to the level of 5-7.5mg (2-3 tablets).

When using the medication for treatment of Parkinson disease with optimal tolerance of patient the use of Parlodel should start with the smallest dose of 1.25mg (half a tablet), which should be taken one time a day (better in the evening) for a period of one week. The dose of Parlodel used for treatment can be increased gradually, until reaching the minimal efficient dose for treatment. It is necessary to increase the dose very gradually by 1.25mg per week and divide the daily dose into several intakes (2-3). The treatment usually gives significant result after 6-8 weeks of intake of the mediation. If there is no effect after such period of time, then it is necessary to further increase the dose by 2.5mg per day at a one week interval.

Usual dose of Parlodel used for treatment in mono-therapy or in combined treatment varies from 10 to 40mg, although some people need bigger doses for treatment.

If when taking certain dose of drug, you develop side effects, it is necessary to lower the daily dose until receiving the better condition of a patient. The dose should be lowered at one week interval. When side effects go away, it is possible to increase the dose for treatment again.

6. Counterindications
– arterial hypertension in pregnancy;
– non-controlled arterial hypertension;
– serious diseases of cardio-vascular system and cardio ischemia;
– arterial hypertension in an early and late post-natal period;
– hyper sensitivity to the components of Parlodel or other alkaloids of ergot;
– severe mental illnesses at the moment or in anamnesis.

7. Should Be Taken with Precautions, if…
The medication has to be taken with caution as there were individual cases, when its use developed stomach ulcers and bleedings from intestinal tract. The treatment with Parlodel should be discontinued, if such conditions progress.
The medication should be used with special caution during post-natal period.
There were rare cases with progression of serious side effects, such as myocardial infarction, arterial hypotension, convulsions, psychic disturbances in women and cerebral insult in patients, using Parlodel during the post-natal period in order to depress the lactation. Soma patients suffered from distortion of circulation in brain and convulsions, which were followed by severe headaches and transient vision disorders. When the medication is used for treatment of women in post-natal period, as well as other patients, who are regularly using Parlodel for treatment, it is necessary to regularly measure AT.

8. Interface with Other Medications
The medication sho9uld be used with special care for treatment of patients, who have recently been taking or still are taking mediations, which affect arterial tension.
In order to take any medications simultaneously with use of Parlodel, it is better to consult a doctor.

9. Overdosing
- vomiting,
- nausea,
- dizziness,
- drowsiness,
- diminution of arterial tension,
- hallucinations.
There were no lethal outcomes registered.

10. Side Effects
For the first few days of treatment the medication has the ability to cause such side effects, like nausea, and in rare cases � general weakness, dizziness, vomiting. If such side effects appear, there is no need to cancel treatment, as they will go away as treatment continues.
Parlodel has the ability to seriously affect arterial tension, which can cause collapse. It is necessary to constantly control AT, especially during first days of treatment.

It is known that in some cases Parlodel caused constipation, stuffiness in nose, headaches and drowsiness and, less often cases, psychomotor agitation, mental confusion, hallucinations, dryness of mouth, dyskinesias, convulsions of calves, loss of hair and allergic skin reactions. Such side effects usually depend on the dose and can be eliminated by lowering the dose of Parlodel.

In some cases of long-term use of Parlodel the medication caused inversive blanching of finger points and that of toes as a response of body to cold, particularly in patients who had previously problems with Raynaud’s syndrome.
Administration of Parlodel in order to depress physiologic lactations in the post-natal period is usually accompanied with development of myocardial infarction, arterial hypertension, convulsions, psychical distortion (in seldom cases), cerebral insult.

11. Pregnancy and Lactation
If a patient is planning to get pregnant or already is pregnant, use of Parlodel should be discontinued as soon as pregnancy has been confirmend, apart from the cases, when there are clinical indications, that make the patient to continue intake of the medication. Stopping of Parlodel treatment in process of pregnancy didn�t cause increasing of the number of cases of unprompted miscarriage. There has been a lot of experience of use of Parlodel during pregnancy, which shows that the medication does not have any affect on the course of pregnancy or its outcome.
When a patient suffers fro pituitary adenoma and gets pregnant, the treatment with Parlodel is cancelled, and it is necessary for a patient to be cautious in the period of all terms of gestation. In case of having any symptoms of severe increasing of prolactinoma, for example in case of having coning vision and headhaces, the treatment with Parlodel can be started over, or it will be necessary to use surgical treatment.
Parlodel should not be used in the process of breast-feeding, as it has the ability to suppress lactation.
Treatment with Parlodel has the ability to restore productive anilities. If Parlodel is used for treatment of women of child-bearing age, who are not trying to get pregnant, sufficient contraceptive methods should be used during treatment.

12. Driving
When the medication is used for treatment, whose professional activity involved operation of mechanisms and driving of vehicles, patients should be especially careful, as during the start of treatment with Parlodel, the medication may cause progression of arterial hypotension, which can affect the speed of reaction.

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Q. How do I track my order of Parlodel ?
A. At this time, your order is sent through Registered Mail, which provides delivery confirmation but not real-time tracking.If you need to know the status of order Parlodel or ask for a reshipment, please do not hesitate to get in touch with us.You are provided with real-time order status updates via our order status form, found on the left-hand side of the screen.

Q. How do I cancel my order of Parlodel ?
A. If you wish to cancel your order, you must let us know before 11am EST the following day. We will not be able to cancel any orders after this time. For all cancellations, please contact us.

Q. Can you tell me if I should be taking Parlodel ? Or, will it work for me?
A. We cannot advise you in any capacity in this matter. You should not take any medication without consulting a physician first.

Q. What is your returns policy?
A. By law, we regret that we are unable to accept returned pharmaceuticals. If your purchase is defective in any way, we will be pleased to replace it at no cost to you.

Q. What is your refund policy
A. Refunds are solely at our discretion. If you are not satisfied with the product or service provided, contact us immediately via email with your order number. We will investigate and work hard to resolve the issue to your satisfaction. Sometimes this can take up to 10 business days. If the matter cannot be resolved, we will issue refunds as necessary.

Q. What is your cancellation policy
A. We debit your Credit Card only once we have shipped your order. Therefore, if you wish to cancel your order prior to us charging your card you will be able to do so without penalty. Once your order has been shipped we will be unable to cancel your order.

Q. What about importing of Parlodel to my country ?
A. Importation of prescription medication is legal in most countries (including the US, UK, France, Spain, Hong Kong, Japan and S. Korea) provided the medication is for personal use and is not a controlled substance. If you are in doubt about the situation in your country, check with your local Post Office.