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Sildenafil citrate and pulmonary arterial hypertension

Pulmonary arterial hypertension

Definition “pulmonary arterial hypertension” is related to a group of diseases characterized by:

-  Progressive increase in pulmonary vascular resistance;

-  Reduction in pulmonary bloodflow;

-  High pulmonary artery pressure;

-  Contractility of the heart right ventricle;

-  Right ventricular failure.

 

Pulmonary arterial hypertension may be caused by:

-  Anorexigenic drug abuse (fenfluramine, dexfenfluramine…);

-  Uncontrolled psychoactive drugs consumption (amphetamine, cocaine…);

-  Long use of synthetic chemotherapeutic drugs (sulfadiazine, sulfamerazine…);

-  An organism intoxication by rape oil or nicotine;

-  HIV-infection;

-  Pathological thyroid disorder;

-  Congenital shunts between the system and pulmonary vessels;

-  Acute/chronic diseases of the liver;

-  Metabolic disorders (obesity);

-  Genetic mutations (revealed and confirmed during control clinical study).

 

The main symptoms of pulmonary arterial hypertension are:

-  Undue fatigability;

-  Apnea (sometimes – during sleep);

-  Dizziness and faint;

-  Peripheral hypostases;

-  Non-productive cough (dry cough);

-  Acute chest pain (stenocardia).

 

Pulmonary arterial hypertension is diagnosed after a medical examination where the following pulmonary arterial hypertension symptoms are revealed:

-  A loud pulmonic valve closing;

-  Distention of jugular veins running  down the side of the neck near to the carotid artery;

-  Bulging neck veins at pressing over the liver (hepatojugular reflux);

-  Edema in feet.

Pulmonary arterial hypertension is a rare but serious disease. Life expectancy in adults is 3-5 years only, and an intensive treatment may help to 10-12 years. Life expectancy in children depends on the age. Five-year survival is 88 % in kids under 6 years old against 25 % of five-year survival in children above 6 years old.

Progress in genetics and molecular biology helps to study a pulmonary arterial hypertension mechanism to design new methods in treatment of pulmonary arterial hypertension.

Clinical trials revealed that nitrogen oxide synthesis is disordered in pulmonary arterial hypertension. Dilating blood vessels, nitrogen oxide stimulates the bloodflow, consequently, if nitrogen oxide level is decreased, an acute lack of blood supply to the myocardium is observed.

Nitrogen oxide inhalation has been used before as a preventive mean. But a long treatment course was inconvenient.

Nitrogen oxide inhalation is an effective therapy remedy for post-surgery pulmonary arterial hypertension in children as process of pulmonary vessels remodeling in children can be prevented and even reversed, however this method of pulmonary arterial hypertension treatment is less effective in adults.

Nitrogen oxide inhalation was replaced by strong medications increasing nitrogen oxide action and initiating a biochemical cascade to decrease a smooth vessels muscles tone.

The first drug relaxing vessels walls and reducing pulmonary artery resistance was Sildenafil citrate known better all over the world under Viagra brand name.

Under clinical trial results submitted by Pfizer in 2005, FDA approved Sildenafil citrate for treatment of pulmonary arterial hypertension, including in patients with liver/kidneys disorders and in advanced age.

Sildenafil citrate and pulmonary arterial hypertension

For today it is confirmed that:

-  Sildenafil citrate reduces the pulmonary vascular resistance and pulmonary artery pressure;

-  Sildenafil citrate reduces the right ventricle press;

-  Sildenafil citrate reduces symptoms of right-side congestive heart failure;

-  Sildenafil citrate improves haemodynamics;

-  Sildenafil citrate prevents pulmonary arterial hypertension symptoms development;

-  Sildenafil citrate restores impellent activity against insufficient blood circulation;

-  Sildenafil citrate increases survival rate for patients with pulmonary arterial hypertension;

The main advantage of Sildenafil citrate is that it relaxes the pulmonary arteries walls without affecting the general blood circulation.

To achieve stable pharmacological effect, Sildenafil citrate is included in the standard treatment scheme in combination with Epoprostenol, Iloprost and Bosentan. Thus it should be considered that:

-  Sildenafil citrate increases hypotensive nitrate action (Isosorbide dinitrate, Nitroglycerin);

-  Sildenafil citrate increases antiplatelet effect of Sodium nitroprusside (brand name Nitropress);

-  If antifungal drug Ketoconazole, antiulcer drug Cimetidine or antibiotic Erythromycin were included in a complex drug therapy, a daily dose of Sildenafil citrate should be reduced as the said drugs increase Sildenafil citrate concentration in the blood.

Sildenafil citrate dosage in pulmonary arterial hypertension treatment may vary from 25 to 100mg / 2-3 times a day, thus a daily dose of Sildenafil citrate exceeding 200mg is to be taken under the doctor’s observance.

Sildenafil citrate is characterized by a high pharmacological activity and tolerated well in senior age. It helps to improve the life quality of people with pulmonary arterial hypertension.

Sildenafil citrate is an international name of acting component available under different trademarks around the world. If you want to buy Sildenafil citrate, but your local drugstores order an expensive brand Viagra (Pfizer) only, you can buy Sildenafil citrate without prescription on online pharmacy. Buying Sildenafil citrate without prescription you always have a possibility to consult the pharmacist online and ask any question.

The pharmacist’s consultation is free of charge when you buy Sildenafil citrate online without prescription for treatment of pulmonary arterial hypertension.

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